• The Cx family of integral membrane

  2022-08-13

  

  The Cx family of integral membrane proteins [13] are key components of the Gap Junction channels that provide GJIC, which is indispensable in the preservation of tissue integrity and homeostasis in multicellular organisms. Gap Junction channels form a conduit for exchange of ions (Ca2+), second mess

• Herein we describe the development of second generation GSM

  2022-08-13

  

  Herein, we describe the development of second generation GSM compounds aimed at improving critical physicochemical properties while maintaining the potent activity of the parent AGSM. Ligand design focused on identifying heterocyclic replacements for the hydrophobic D-ring as a means to improve ADME

• It is well known that TNF plays a

  2022-08-13

  

  It is well known that TNF-α plays a pivotal role in the pathogenesis of RA. TNF-α influences diverse pathologic processes including joint destruction as well as inflammatory responses [16]. While TNF-α significantly increases the levels of sFas and mFas expression from FLS, IL-1β and IL-17 have mini

• L-Arabinose br Discussion Our results showed

  2022-08-13

  

  Discussion Our results showed that the histamine H1 receptor antagonist/inverse agonists, pyrilamine and cetirizine, attenuated not only NMDAR-mediated synaptic current but also LTP in Shaffer collateral-CA1 pyramidal neuron synapses. The H1 receptor antagonist/inverse agonist-induced attenuation

• br Results br Discussion In this study we found

  2022-08-13

  

  Results Discussion In this study, we found that ZNF280A was elevated in CRC tissues and a high expression of ZNF280A correlated with advanced clinicopathological features, poor prognosis, and disease progression in CRC patients. Furthermore, silencing ZNF280A attenuated proliferation and inhib

• Finally we find that in the absence of Aurora

  2022-08-12

  

  Finally, we find that in the absence of Aurora B, Sgo1 is delocalized from centromeres and found along chromosome arms, as reported after depletion of Bub1 (Kitajima et al., 2005, Riedel et al., 2006). The increased arm cohesion observed in the absence of Aurora B activity is dependent on the presen

• An interesting question is why RhoF has

  2022-08-12

  

  An interesting question is why RhoF has such the slow rate of GDP dissociation. The amino 8-CPT-2Me-cAMP, sodium salt receptor mutations in a presumable GDP-binding site of RhoF had only moderate effects on the GDP dissociation (Fig. 3C), which suggests a mechanism involving the global amino acid se

• Type diabetes mellitus T DM causes vascular complications

  2022-08-12

  

  Type 2 PF-573228 (T2DM) causes vascular complications and is a major public health problem associated with lifestyle diseases such as obesity, liver steatosis, hypertension, and so on. Although serum lactate is reportedly elevated in diabetic patients [12], [13], the physiological effects remain unc

• Several studies have proposed that high

  2022-08-12

  

  Several studies have proposed that high levels of KYNA in the all the money contribute to cognitive dysfunctions presented by patients who suffer from schizophrenia [30], [31], [32], [33]. Considering that: (i) KYNA is a known GPR35 agonist [2], (ii) cognitive impairments in patients with schizophre

• br Conflict of Interest Both GM and BDH

  2022-08-12

  

  Conflict of Interest Both GM and BDH are shareholders in Caldan Therapeutics, a company exploring potential novel treatments for type 2 diabetes. Acknowledgments Work described herein was supported by Biotechnology and Biological Sciences Research Council [grant BB/K019864/1)] (to GM) and [gr

• Methods br Results br Discussion The current study is the

  2022-08-12

  

  Methods Results Discussion The current study is the first to specifically investigate the role of hepatic GPR109A and GPR109B on HDL metabolism and response to niacin therapy. While niacin raises HDL-C levels in humans, it has been reported by others [20], [36] and confirmed by us here that n

• Histamine functions as a key neurotransmitter in

  2022-08-12

  

  Histamine functions as a key neurotransmitter in multiple circuits to control various behaviors. In Drosophila photoreceptor, SIN-1 chloride is produced de novo by histidine decarboxylase (Burg et al., 1993); meanwhile, maintaining normal histamine content also depends on the histamine recycling pa

• br Conclusion Until recently astrocytes were recognized sole

  2022-08-12

  

  Conclusion Until recently, astrocytes were recognized solely for their maintenance role in the regulation of JWH 015 homeostasis. Nowadays, this idea has changed, it is clear that these cells play a crucial role in the regulation of neuronal activity and signal transmission. In particular, glial

• A number of experimental data declare a tight interdependenc

  2022-08-12

  

  A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in mmae and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shrivastava, 2013

• br Xenobiotics and the Glucocorticoid Receptor

  2022-08-12

  

  Xenobiotics and the Glucocorticoid Receptor Conclusion Transparency document Acknowledgements The author wishes to thank Professor Wilhelm Engström from the Swedish University of Agricultural Sciences (Department of Biomedical Sciences and Veterinary Public Health) for his proof reading

15549 records 407/1037 page Previous Next First page 上5页 406407408409410 下5页 Last page