• How changes in APP processing by

  2022-01-11

  

  How changes in APP processing by γ-secretase lead to AD is still not well understood. Deposition of amyloid beta (Aβ) peptide fragments of the amyloid precursor protein (APP) in amyloid plaques and hyperphosphorylated tau in neurofibrillary tangles are the cellular hallmarks of AD (O’Brien and Wong,

• Now we turn to the

  2022-01-11

  

  Now we turn to the other channel through which the risk-taking incentives provided by option compensation affect corporate debt maturity. Jensen and Meckling (1976) argue that the payoff structure of debt holders in a levered firm is concave, while that of equity holders is convex, thus, shareholder

• Sperm capacitation was negatively r p related with CR while

  2022-01-11

  

  Sperm capacitation was negatively (r = −0.68; p ive but not significant (r = 0.22). No significant relationship was observed between the expression levels of either CB1 receptor or FAAH and any of the sperm quality parameters studied. The scatter plot distribution of spermatozoa expression of CB1 an

• br Acknowledgments This work was

  2022-01-11

  

  Acknowledgments This work was supported by the National Natural Science Foundation of China (31100111), the Nature Science Research Project of Anhui Province (1508085MC43), the subject construction project from Anhui Academy of Agricultural Sciences (14A1110). We would like to acknowledge the tec

• In hypoxic breast cancer cells BNIP mediated autophagy activ

  2022-01-11

  

  In hypoxic breast cancer cells, BNIP3-mediated autophagy activation and elevation of amino akt inhibitors levels were notable. BNIP3, a BCL-2 family protein, is known to be transcriptionally regulated by HIF-1α and to be involved in cancer cell death in hypoxic conditions [51]. As a link to autopha

• br Tissue Specific Roles for HIF PHD Isoforms Hypoxia

  2022-01-11

  

  Tissue-Specific Roles for HIF/PHD Isoforms Hypoxia signaling pathways are active in almost all mammalian cells, including immune Ibrutinib and tissues such as the epithelium and endothelium. This is of crucial importance when considering the influence of environmental hypoxia in inflammatory con

• Studies conducted in our laboratory thus

  2022-01-11

  

  Studies conducted in our laboratory, thus far, have shown that HKDC1 is broadly expressed [28]. Using the first developed HKDC1 mouse model, we found that complete loss of HKDC1 function is embryonic lethal, similar to other HKs [29,30]. Further studies using HKDC1 heterozygous knockout mice showed

• Glutathione in reduced form GSH

  2022-01-11

  

  Glutathione in reduced form (GSH, the tripeptide, γ-glutamyl cysteinyl glycine) is a non-enzymatic low-molecular-weight antioxidant necessary for the maintenance of a cellular redox state (Noctor et al., 2012). At the stage of the transition from germination to seedling growth the process of cell di

• AY 9944 dihydrochloride br Materials and methods br Results

  2022-01-11

  

  Materials and methods Results Discussion Disclosures Author contributions Acknowledgements Introduction Diabetes mellitus is one of the fastest growing chronic diseases worldwide, with an estimated prevalence of 382 million patients, of which about 90% have type 2 diabetes melli

• Alpha synuclein AS is a protein located in

  2022-01-10

  

  Alpha synuclein (AS) is a protein located in presynaptic terminals of neurons that functions in recycling and storage of neurotransmitters [17]. Under conditions of inflammation and oxidative stress, AS proteins misfold and accumulate into Epalrestat [81], [90]. The aggregates of misfolded AS oligim

• SB742457 br Acknowledgments br Introduction Postmenopausal o

  2022-01-10

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by SB742457 deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of po

• Besides the described effects on gross

  2022-01-10

  

  Besides the described effects on gross locomotor function, impairment of visuo-motor coordination and fine-motor skills like resting tremors, bradykinesia and rigidity were also investigated, reflecting on the symptomatology of Parkinson's disease in humans (Inzelberg et al., 2008). Preclinically, t

• br Materials and methods br Conflicts of interest

  2022-01-10

  

  Materials and methods Conflicts of interest Some of the peptidomimetic compounds in this work are the subject of the patent application “Peptidomimetics for Imaging the Ghrelin Receptor”, WO/2016/191865 A1, December 8th, 2016. Acknowledgements Special thanks go to Rebecca McGirr (Lawson He

• br Materials Aspergillus oryzae GS U mg solid

  2022-01-10

  

  Materials Aspergillus oryzae βGS (8.4 U mg−1 solid) was obtained from Sigma-Aldrich Chemicals Co. (USA). o-Nitrophenyl β-d-galactopyranoside (ONPG), sodium carbonate, zinc chloride, manganese chloride, calcium chloride and potassium chloride were procured from Sisco Research Laboratories (SRL), M

• In patients with breast cancer ZRANB gene amplification was

  2022-01-10

  

  In patients with breast cancer, ZRANB1 gene amplification was found in a subset of cases, and ZRANB1 protein levels correlated with EZH2 protein levels and poor survival (both TNBC and non-TNBC). Moreover, unlike normal mammary epithelial cells, all human breast cancer cell lines examined (both TNBC

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